* denotes statistical significance (, Assessment of GAG production in the IVD after injection with MPSCs.
Institute for Joint Replacement, Department of Orthopedic Surgery, Kyoto Katsura Hospital, Yamada-hirao-cho, Nishikyo-ku, Kyoto 615-8256, Japan. Journal of Orthopaedic Surgery and Research volume 6, .
Cells were also directly injected into the disk (1,000 cells in 1 µl) or punctured without the introduction of cells (controls). The IV injected group was unable to prevent the puncture-induced loss of disk height and showed a 14.6% decrease in DHI.
Citation: Journal of Orthopaedic Surgery and Research 2021 16 :676. Submission Fee: Nil.
Our finding showed limited homing ability of the MPSCs. Both modes of delivery resulted in increased expression of aggrecan, however only the direct injection of the MPSCs resulted in improved IVD morphology and preserved disk height. Harris haematoxylin was used as a counter-stain and sections were mounted with Aquatex aqueous mounting medium. 2).
The Journal of Orthopaedic Research, a publication of the Orthopaedic Research Society (ORS), is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research, including life sciences, engineering, translational, and clinical studies. Journal of Orthopaedic Surgery and Research Impact Factor, IF, number of article, detailed information and journal factor.
X-ray radiography was used to measure the disk and adjacent vertebral bodies to calculate the %DHI. CAS . Kwok HY, Chiu KY. Hydroxyapatite coated total hip replacement - A review of 77 hips followed up for 2 years. On the same day as surgery, the MPSCs were quick thawed and resuspended in DMEM and injected intravenously (1 × 106 cells in 100 µl) into the tail vein. (2years) Ref. His professional appointments include Chairperson of AOTrauma Global Research Commission, member of Trauma sub-committee of SICOT . 1994, 3: 347-352. IVD were harvested for histological, gene and protein analysis after 14 weeks. Contrasting to direct injection, intravenous injection neither improved the degeneration status, nor preserve disk height, however, both delivery methods increased glycosaminoglycan (GAG) protein and Acan gene expression relative to controls, suggesting possible paracrine effects. The Article Processing Charge (APC) for this journal is $1,500. Mantenimiento, Restauración y Remodelaciónde Inmuebles Residenciales y Comerciales. Found inside – Page 8Journal of Orthopaedic Surgery, 2009;17(3):269-74). For additional information, contact C.H. Pang, Kwong Wah Hospital, Dept. of Orthopaedics and Traumatology, Hong Kong. (2010 MAY 3) MassGeneral Hospital for Children, Boston: Coaptive ... Disk heights were measured, and the DHI of the disk were calculated as previously described,13 where the change in DHI was expressed as the %DHI (post-op DHI/pre-op DHI). At 3 days post-direct injection, MPSCs were observed in the NP space of the IVD (A). Animal models of induced disk degeneration indicate that exogenous mesenchymal stromal cells (MSCs) can be effective at reducing the severity of degeneration3, 4; however, the use of MSCs requires an invasive procedure for their extraction.
2016 Top CORR Reviewers of 2016. NOD/SCID mice aged 6–8 weeks (five mice/group) were used in this study.
/ Doc. Speed 43 days to first decision for reviewed manuscripts only 37 days to first decision for all manuscripts An ISSN is an 8-digit code used to identify newspapers, journals, magazines and periodicals of all kinds and on all media-print and electronic. The journal is published in June and December by SAGE Publishing. Found inside – Page 314Journal of Intellectual Disability Research, 47, 75–84. ... Brief report: Behaviors identified by caregivers to detect pain in noncommunicating children. Journal ... Journal of Orthopaedic Surgery (Hong Kong), 10, 144–151. Hong Kong Journal of Orthopaedic Research covers all field of Medical Sciences including; Medicine Journals, Dental Surgery .
This suggested that the MPSCs may have secreted various growth factors to stimulate local IVD cells or progenitors via paracrine effects, before subsequent migration or cell death. It is the official journal of the Asia Pacific Orthopaedic Association. Richards RR, An K-N, Bigliani LU: A standardized method for the assessment of shoulder function. Indeed, the direct injection of MSCs into a rabbit disk degeneration model was able to lessen the levels of observed degenerative changes.3, 4 Other in vitro studies suggest that direct cell–cell contact of MSCs derived from various tissues including that of human cord blood with IVD cells enhances the production of disk matrix,16-19 and a comparison of direct and indirect co-culture of MSCs with IVD cells indicated that direct cell contact is important for the differentiation of the MSCs towards an NP-like phenotype.18, Despite the IV delivery of cells being less able to preserve the morphology and disk height compared to direct injection of cells, aggrecan was actively produced by IVD cells as a result of the MPSCs.
3 School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. IVD were labeled with collagen II and aggrecan antibodies, developed with fast red and counter-stained with Harris haematoxylin. The total amount of GAG in the IVD was determined by the DMMB assay.14 Tail disk were excised endplate to endplate and snap frozen, lyophilized to a constant mass and weighed, and digested overnight with proteinase K (0.05 mg/ml, Roche, Germany) at 60°C.
Aims and Scope (from publisher): Journal of Orthopaedic Surgery is an open access peer-reviewed journal publishing original reviews and research articles on all aspects of orthopaedic surgery.
His current clinical focus is on the use of robotic arm assisted technology to perform cementless total knee arthroplasty in the younger and more active patients. 1 Department of Orthopaedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands. It is the official journal of the Asia Pacific Orthopaedic Association. The roles of the Centre are to demonstrate high standard of research that are attainable in sports medicine and sports sciences in Hong Kong, to strengthen sports medicine and sports health education training for allied health staff for a high quality of services, to provide high-quality medical services to the athletes and amateur sportspeople, and to encourage exercise for health . General The Journal of Orthopaedic Science is the official peer-reviewed journal of the Japanese Orthopaedic Association. Found inside – Page 9391( NLD † Journal of Osteopathic Education and Clinical vurnal of New Music Research . ( NLD ISSN Journal of Nurses ... ( USA ISSN 0955-2863 ) 5899 ( USA ISSN 0149-886X ) 5375 Gynaecology ( Hong Kong Edition ) . ( HKG SSN 0195-9298 ) 3048 ... The Journal of ISAKOS (JISAKOS) is an online only orthopaedics journal that synthesizes the latest research and evidence-based guidelines in orthopaedic sport… There was a 29.1% decrease in the DHI of the punctured control in comparison to the non-punctured control (Fig. We tested the effects of these cells on injured IVD using a mouse model of puncture-induced degeneration via two delivery methods. Journal of Orthopaedic Surgery: Journal Indexing and Metrics. The MPSCs come from a reliable and ready source to use in which the umbilical cord is usually discarded after birth, as opposed to MSCs, which requires an invasive procedure to extract them.
Found insideJournal of Orthopaedic Trauma can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, ... According to news originating from Hong Kong, People's Republic of China, by NewsRx correspondents, research stated, ... Anatomy of L4 to S3 nerve roots. - preview & related info ... Physical Therapies in Sport and Exercise - Page 58 Similar to the IV injection of cells, directly injected cells did not persist to the 14 week time point, although they were confirmed to be present in the IVD shortly after direct injection. Found inside – Page 8619767801773 J Orthop Surg ( Hong Kong ) Journal of orthopaedic surgery ( Hong Kong ) 1022-5536 ( P ) Continues : Journal of the Western Pacific Orthopaedic Association . 19939440382 J Pediatr The Journal of pediatrics . 2011-2013, Member, Scientific Review Panel on Biology and Medicine, Hong Kong Research Grants Council 2010-2015, Member, Advisory Committee, University of Pittsburgh Stem Cell Core 2010-present, Co-Director, Armed Forces Institute of Regenerative Medicine (Wake Forest University and University of Pittsburgh) Journal of Orthopaedic Surgery and Research Key Factor Analysis Journal of Orthopaedic Surgery and ResearchのISSNは 1749-799X . 6B).
Disk were excised endplate to endplate, frozen and embedded in deionized water, and the NP was cryosectioned to a thickness of 5 µm. The amount of GAG was calculated with reference to a standard curve made by serial dilutions of chondroitin-4-sulphate (C4S, Sigma–Aldrich, St. Louis, MO) and expressed as the GAG content as amount of C4S per dry mass. Furthermore, the MPSCs can be readily expanded to high numbers from a low starting number using a defined culture medium, and they exhibit expanded multipotency in comparison to MSCs.9, 10 Even with restricted homing capacity and limited ability to physically penetrate the injured IVD in high numbers via IV delivery, they were still able to induce increased production of aggrecan matrix in the IVD, and also have the added advantage of repeated treatments if necessary. 6B) and direct inject groups (data not shown).
Knee Surgery & Related Research covers all aspects of knee surgery relating to knee joint diseases, trauma and treatment as well as basic research with clinical relevance.Knee Surgery and Related Research is the official journal of the Korean Knee Society with affiliation of the Asian societies relating Knee joint; Thailand Hip and Knee Society, Taiwan Joint Reconstruction Society, Indonesian . Hong Kong Journal of Orthopaedic Research is a peer reviewed journal committed to the dissemination of high-quality research related to the latest trends and advances in orthopaedics, trauma, orthopaedic rehabilitation and related knowledge from all over the world. Found inside – Page 250Orthopaedics, 10, 1533–1539. Armstrong, M. S., Spencer ... Journal of Biomedical Materials Research, 24, 573–580. Askew, M. J., Steege, J. W., ... Journal of Orthopaedic Surgery (Hong Kong), 12, 194–198. Bean, D. J., Hollis, J. M., Woo, ... Hong Kong Journal of Orthopaedic Surgery 1999; 3(1):33-39. Hong Kong Journal of Orthopaedic Research (eISSN 2663-8231) is a peer reviewed journal committed to the dissemination of high-quality research related to the latest trends and advances in orthopaedics, trauma, orthopaedic rehabilitation and related knowledge from all over the world. One million cells was chosen for IV injection due to the anticipation of the cells circulating through the whole body before reaching the IVD, and the potential of cells lodging at other sites such as the lungs.
13 Department of Orthopaedic Surgery, Geisinger Medical Center, Danville, Pennsylvania. However, if the first author or corresponding author of the submission is a member of the Asia Pacific Orthopaedic Association, a reduced APC of $1000 will be applicable. The most direct route is an injection into the affected IVD, ensuring a localized therapeutic effect. Cheng, JCY, Tang, SP, Guo, X, Lee, KM & Qin, L 2001, ' An immunohistochemical study on expression of decorin and biglycan in bone of osteopenic adolescent idiopathic scoliosis girls ', Hong Kong journal of orthopaedic surgery (香港骨科醫學雜誌), vol.
Journal of Orthopaedic Surgery is an open access peer-reviewed journal publishing original reviews and research articles on all aspects of orthopaedic surgery.
Sections were dewaxed and underwent proteinase K (20 µg/ml) antigen retrieval for 10 min at room temperature (RT). It allows orthopaedic surgeons and scientists of the Asia Pacific Region to continuously update themselves with the latest discoveries and advances of orthopaedic . Knee Surgery and Related Research is the official journal of the Korean Knee Society, . Somos una empresa dedicada a la prestación de servicios profesionales de Mantenimiento, Restauración y Remodelación de Inmuebles Residenciales y Comerciales. Found inside – Page 9188410047 see Journal of the Nutrition Association of Thailand Photchanākān sān ISSN 0736-0266 = Journal of Orthopaedic research . 1. ... Orthopaedic Research Society . ... ( Hong Kong : Medpro Pacific , v . : ill . Found inside – Page 4Hong Kong Medical Journal I Xianggang Yi Xue Za Zhi, 2010;16(6):476-9). For additional information, contact A.W. Fok, Queen Mary Hospital, Dept. of Orthopaedics and Traumatology, Pokfulam, Hong Kong. (2011 JAN 4) Sanford-Burnham Medical ...
However, in vivo studies suggest that needle injection into the IVD may cause further degeneration.5-7 In fact, many studies use needle puncture as a model system to study disk degeneration in animals.3, 4, 8. ng, PT, PhD3 a chilles tendon ruptures are common in athletes and the middle-
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