Registered VAT no. A limited number of clinical trials show short-term efficacy of topically applied, alkaloid-free comfrey preparations in skin abrasions and inflammatory conditions. View abstract. Avoid with medications that induce CYP3A4 or are hepatotoxic (Natural Medicines, 2020). Koll, R., Buhr, M., Dieter, R., Petrowicz, O., Gianetti, B., and Wagener, S. Wirksamkeit und Vertraglichkeit von Beinwellextrakt (Extr. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Medically reviewed by Drugs.com on Feb 8, 2023. This site uses cookies to improve your experience. Ther Drug Monit 2001;23:698-708. Comfrey contains chemicals called. Giannetti, B. M., Staiger, C., Bulitta, M., and Predel, H. G. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo controlled, multicentre trial. View abstract. Do not use this product without medical advice if you are breast-feeding a baby. Add cup of the comfrey tincture and all essential oils to the cooled oil/butter mixture. Seal with a lid and then label with the ingredients and date. Commercial comfrey sale and distribution is restricted in Germany and Canada because of its substantial toxicity. Hybrids and other species may have a similar appearance but could have significantly different amounts of the toxic pyrrolizidine alkaloids (Kucera et al., 2018). 2018;19(5):455-474. doi:10.1016/j.jpain.2017.11.005, Gagnier JJ, Oltean H, van Tulder MW, Berman BM, Bombardier C, Robbins CB. Pyrrolizidine alkaloids are very toxic to the liver and are also carcinogenic (cause cancer). View abstract. Close LOGIN FOR DONATION. Comfrey root: from tradition to modern clinical trials, Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo-controlled, multicentre trial, Topical herbal therapies for treating osteoarthritis, Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials, Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial. Comfrey cream contains several active components (substances). Z Phytotherapie 2000;21:127-134. Wound-healing effects of a symphytum herb extract cream (. Am J Med 1990;89:547-8. Anotherstudy found that comfrey ointment was superior to placebo in relieving pain and stiffness in osteoarthritis. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. Links to external sites are for informational purposes only. Symphytum officinale L, S. asperum Lepechin, S. tuberosum L, Symphytum x uplandicum Nyman. Make sure to always buy comfrey (Symphytum officianale) root and leaf from a trusted source. Save the remaining liquid alcohol portion. Company number 02758955 Registered VAT number 211727395. Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: Results of a randomized controlled clinical double-blind study. View abstract. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. She is passionate about providing evidence-based recommendations that make health decisions easier and improve lives. In some cases, ointments with comfrey have caused redness, itching, and a rash (Smith, 2011). Using it no more than four to six weeks a year as a general guideline would be best. Comfrey shouldn't be used in any form during pregnancy or nursing due to the risk of liver damage to infants. A handbook for practice on a scientific basis. All Technology Jobs. Glass bowl with a lid Safety Alerts & Advisories: FDA Advises Dietary Supplement Manufacturers to Remove Comfrey Products From the Market. Efficacy and tolerance of a comfrey root extract (Extr. Consult your healthcare provider before using comfrey cream. (10), 707-714. https://doi.org/10.1016/j.phymed.2005.06.001. Bleakley, C. M., McDonough, S. M., and MacAuley, D. C. Some conservative strategies are effective when added to controlled mobilisation with external support after acute ankle sprain: a systematic review. Drug-induced liver injury. View abstract. Comfrey cream Limited trials have evaluated the effectiveness of alkaloid-free preparations for external use; however, these studies did not examine how much liver damage occurred in patients. Effects of Symphytum ointment on muscular symptoms and functional locomotor disturbances. Using a supplement like comfrey may have potential side effects. We go to great efforts to ensure that the information on this page is accurate at the time that the page was last edited. The warm weather has a way of encouraging us to get outside and move our bodies more. If you choose to use comfrey, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Comfrey should not be used in place of medication prescribed for you by your doctor. Do not use different forms (tablets, liquid, tincture, teas, etc) of comfrey at the same time without medical advice. Frost R, Macpherson H, O'meara S. A critical scoping review of external uses of comfrey (Symphytum spp.). One study followed 142 patients with ankle sprains. cup organic safflower oil Transfer the cooled oil and butter mixture to a standing electric mixer or blender. For topical comfrey cream, look for products labeled as free of pyrrolizidine alkaloids. The cream was applied to the local lumbar area 4x during the day of the exercise, with the first application being pre-exercise (Jurcau & Jurcau, 2013). Double boiler Three clinical studies have provided evidence that ointments containing comfrey root have helped reduce back pain. View abstract. For External Use only Do not use if you are sensitive to any of the ingredients. Comfrey has also been used for the following conditions: There is currently not enough evidence to recommend comfrey cream for any of these uses. Looks like you may need to upgrade your browser We're sorry, we no longer support the web browser that you are using 2016 Jan;41(2):116-33. doi:10.1097/01.brs.0000249525.70011.fe. https://doi.org/10.1007/s10354-007-0474-y. Kucera, M., Kalal, J., and Polesna, Z. Herbal medicine for low back pain: A Cochrane review. View abstract. Thank you, {{form.email}}, for signing up. Barna, M., Kucera, A., Hladicova, M., and Kucera, M. [Wound healing effects of a Symphytum herb extract cream (Symphytum x uplandicum NYMAN: ): results of a randomized, controlled double-blind study]. Children, who suffer from these injuries the most, are statistically unlikely to have adverse reactions to comfrey oil when used on scrapes.5, When comfrey was applied topically to animals above where theyd suffered bone fractures, their bones healed at a much-improved rate than animals who hadnt been treated with comfrey.6, Leg ulcers are uncomfortable, prone to infection, and can take a long time to heal. hollandandbarrett.ie is a trading name of Holland & Barrett Retail Limited. 1. Journal of chiropractic medicine, 10(3), 147-156. https://doi.org/10.1016/j.jcm.2011.01.003, Stam, C., Bonnet, M. S., & van Haselen, R. A. Retrieved from, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=295. Comfrey flowers are bell-shaped and purple, pink, or pale yellow in color, and it has a dark taproot. 2012;20(11):1209-1216. We comply with the HONcode standard for trustworthy health information. An ankle sprain can come out of nowhere and cause a lot of pain, limitations, and regret until it is healed. Copyright Holland & Barrett Limited 2023. June 3, 2022 Posted by: Category: Uncategorized; No Comments . Thus, it is not advised to ingest herbal preparations of comfrey unless guided by an expert pharmacologist and physician. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. It produces clusters of purple, blue, and white flowers, and it's famous for its long . comfrey cream holland and barrett. Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: Results of a randomized controlled clinical double-blind study. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. doi:10.1002/ptr.4612, Salehi B, Sharopov F, Boyunegmez Tumer T, et al. Penetration of lycopsamine from a comfrey ointment through human epidermis. Skip the missed dose if it is almost time for your next scheduled dose. Without overexposure to air or heatand without cross-contaminationthe recipe should last as long as the expiration date of the carrier oils used. Shop buy 1 get 1 half price on all gut health products, Buy 1 get 1 Half Price | Plus an extra 20% off 25, App Exclusive | Get an extra 22% off 25 when you spend on the H&B App, Royal Mail strikes may cause a delay to our click and collect service, Looking for fitness advice & inspiration this New Year? The use of babosa (Aloe vera) in treating burns: a literature review. Comfrey can kill. Symphyti) in the treatment of ankle distorsions: Results of a multicenter, randomized, placebo-controlled, double-blind study. Toe was infected and painful. Eucalyptus oil is used externally to stimulate blood flow. Some people ingest comfrey roots or leaves or use them in teas. Liver injury from herbal and dietary supplements. In a randomized, controlled, double-blind study with 203 patients, applications of a 10% comfrey cream were well tolerated, reduced swelling and pain, and improved mobility (Kucera et al., 2004). All rights reserved. 211727395. Giannetti, B. M., Staiger, C., Bulitta, M., & Predel, H. G. (2010). View abstract. To reduce the risk of side effects, never apply comfrey cream to broken skin or open wounds as it may be more highly absorbed by the body. Squish and squeeze as many leaves into as you can into the container. reduce lower back pain (Stam et al., 2001). Our Two Pennies Worth. This perennial can grow up to 4-feet tall. Additionally, because its alkaloids are absorbed through the skin, use of comfrey as a poultice should not exceed an exposure of 100 mcg/day of the alkaloids. A few studies show that comfrey cream may be helpful in the treatment of ankle sprains. Kuera, M., Barna, M., Horek, O., Kovrikov, J., & Kuera, A. Additionally, there is scientific research demonstrating comfreys effectiveness at soothing muscle and joint pain, some of which are highlighted in this post. Facebook; Twitter; Pinterest; Related Posts. Comfrey is changed and broken down by the liver. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Copyright Holland & Barrett Retail Limited, 2022. Simply massage into the skin as required. Barna, M., Kucera, A., Hladikova, M., & Kucera, M. (2012). Buy 1 get 1 Half Price on Vitamins & Supplements, Popular Vitamins & Supplements Subscriptions, Buy 1 get 1 Half Price gut health supplements, Guide to sleeping better natural sleeping remedies, Living in the now, gut health & mental wellbeing, The thing that makes you different makes you special, Bhupesh Panchal, Senior Regulatory Affairs Associate, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908267/, http://www.missouribotanicalgarden.org/PlantFinder/PlantFinderDetails.aspx, http://www.sciencedirect.com/science/article/pii/S0965229913001672, http://www.ncbi.nlm.nih.gov/pubmed/22887778, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363250/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631335/, https://pubmed.ncbi.nlm.nih.gov/22887778/, https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-symphytum-officinale-l-radix_en.pdf, http://pennstatehershey.adam.com/content.aspx?productid=107&pid=33&gid=000234. Wien.Med.Wochenschr. Soaked foot in warm water with a few leaves of comfry. When considering the use of herbal supplements, seek the advice of your doctor. It is called knitbone or boneset, referring to the bone-like growth of its roots. Join rewards for life today and we'll give you 300 points worth 3.00. When harvesting comfrey or buying from a non-commercial supplier, note that there is variety within the species. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. To use on established plants, dilute 1 part comfrey fertilizer in 15 parts water. Topical comfrey is for use only on the skin. When buying commercial brands, seek those that have had the pyrrolizidine alkaloids removed, if possible. The Herbal Academy neither endorses them nor is in any way responsible for their content. For this reason, some topical products are advertised as made from comfrey leaves, but it's safest to choose a PA-free product. Verywell Health's content is for informational and educational purposes only. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: results of a double-blind, randomised, bicenter, placebo-controlled trial. A multi-center, randomized, double-blind, controlled clinical trial was conducted with 161 patients having acute lower back pain. Comfrey [Online article]. Barna, M., Kucera, A., Hladikova, M., & Kucera, M. (2012). Poisons Legislation Circular 3-22-1993;60. 6 Healing Benefits of Comfrey. Tolerability and effectiveness of an antitrauma cream with comfrey herb extract in pediatric use with application on intact and on broken skin. A systematic review and quality assessment of case reports of adverse events for borage (Borago officinalis), coltsfoot (Tussilago farfara) and comfrey (Symphytum officinale). Hybrids and other species may have a similar appearance but could have significantly different amounts of the toxic pyrrolizidine alkaloids (Kucera et al., 2018). byBhupesh Panchal, Senior Regulatory Affairs Associate, Comfrey oil is a herbal oil that moisturises skin, and thats been used as a healing herb for a long time.1, Since at least the 4th century, people have used comfrey medicinally. The way that they work is by blocking small blood vessels in the liver. Please simply create an account before buying/booking any courses. These third-party organizations test products to ensure they were manufactured safely and contain the ingredients indicated on the labeling without contaminants. The plant leaves have a lower concentration of PAs than the roots. Do not use this product if you have a sensitivity to any of the ingredients. 16 Rewards for Life points with this purchase. Br J Sports Med. 2004;11(6):470-477. 211727395. Supplements marketed for body-building (ex.. View abstract. International Journal of Pediatrics and Adolescent Medicine, (4), 135-141. https://doi.org/10.1016/j.ijpam.2018.11.002. Comfrey cream combines ingredients like oils or water and glyceryl stearate with Symphytum officinale (comfrey) extracts. Regul Toxicol Pharmacol. This is not recommended due to the presence of chemicals that can cause organ damage and cancer. Those who used the comfrey ointment experienced improvements in pain, mobility, and quality of life. If you're considering using the cream, consult your healthcare provider first. We cover all you need to know in this article. Comfrey (Symphytum officinale) is a plant with yellow or purple flowers found in Europe, Asia, and North America. Ingesting cooking oil has been banned by the European Union, due to a high risk of liver toxicity.9, Adults with liver disease, cancer, or a history of alcoholism are also advised to avoid comfrey because the skin can also absorb the liver-damaging compounds. In a study of 712 children with superficial wounds, applying a 25% comfrey cream for one week or up to two weeks (2-4x day) offered a strong benefit to risk ratio (Kucera et al., 2018).
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